How can i get nitric acid




















Science , — Dykhuizen, R. Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defense. Agents Chemother. Bjorne, H. Intragastric generation of antimicrobial nitrogen oxides from saliva — physiological and therapeutic considerations. PubMed Google Scholar. Nitrite in saliva increases gastric mucosal blood flow and mucus thickness.

PubMed Central Google Scholar. Petersson, J. Dietary nitrate increases gastric mucosal blood flow and mucosal defense. Holm, M. Intragastric CO2 and nitric oxide participate in the regulation of peptone-induced gastrin release in humans. Weiss, S. The nature of the collapse induced by sodium nitrite. Furchgott, R. Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs.

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S -nitrosothiols as active intermediates. Lauer, T. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action.

USA 98 , — Cannon, R. Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. Schechter, A. Hemoglobin and the paracrine and endocrine functions of nitric oxide. Dejam, A. Effects of dietary nitrate on blood pressure.

Larsen, F. Effects of dietary nitrate on blood pressure in healthy volunteers. A report demonstrating a reduction in blood pressure in humans by ingestion of dietary levels of inorganic nitrate. The authors suggest that nitrate is bioactivated in vivo to form nitrite and vasodilatory NO and that this may regulate basal blood pressure. Brooks, J. Google Scholar. Doyle, M. Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.

Huang, K. The reaction between nitrite and deoxyhemoglobin. Reassessment of reaction kinetics and stoichiometry. Huang, Z. Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control.

Basu, S. Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of haemoglobin. Effect of dietary nitrate on oxygen cost during exercise. Oxf , 59—66 Li, H. Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues. Nohl, H. Mitochondria recycle nitrite back to the bioregulator nitric monoxide. Acta Biochim. Castello, P.

Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes. Kozlov, A. Nitrite reductase activity is a novel function of mammalian mitochondria. Various intracellular compartments cooperate in the release of nitric oxide from glycerol trinitrate in liver. Vanin, A. Nitric oxide synthase reduces nitrite to NO under anoxia.

Life Sci. Mechanisms of vasodilatation induced by nitrite instillation in intestinal lumen: possible role of hemoglobin. Redox Signal. Tsuchiya, K. Nitrite is an alternative source of NO in vivo. Malfunction of vascular control in lifestyle-related diseases: formation of systemic hemoglobin-nitric oxide complex HbNO from dietary nitrite.

Hunter, C. Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Webb, A. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. The first report demonstrating cardioprotective effects of nitrite in heart preparations via xanthine oxidoreductase-mediated nitrite reduction to NO. Pluta, R. Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage.

Jama , — Dias-Junior, C. Low-dose intravenous nitrite improves hemodynamics in a canine model of acute pulmonary thromboembolism. Murad, F. Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development. Chen, Z. Identification of the enzymatic mechanism of nitroglycerin bioactivation. USA 99 , — Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation.

Crandall, L. Acquired tolerance to and cross tolerance between the nitrous and nitric acid esters and sodium nitrite in man. Lu, P. Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury.

Hepatobiliary Pancreat. Baker, J. Cell Cardiol. Jung, K. Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injury. Stroke 37 , — Tripatara, P. Cardioprotective effects of vegetables: is nitrate the answer? Nitric Oxide 15 , — Classen, H. Hypothesis: the effect of oral nitrite on blood pressure in the spontaneously hypertensive rat.

Does dietary nitrate mitigate hypertension after conversion to nitrite? Pain, T. Opening of mitochondrial K ATP channels triggers the preconditioned state by generating free radicals. Exposure to nitric acid can cause irritation to the eyes, skin, and mucous membrane; it can also cause delayed pulmonary edema, pneumonitis, bronchitis, and dental erosion. Nitric acid is highly corrosive.

Workers may be harmed from exposure to nitric acid. The level of exposure depends upon the dose, duration, and work being done. Nitric acid is used in many industries. Nitric acid is also used in the polymer industry.

With the chemical formula HNO3 and also known as "strong water", Nitric Acid is a somewhat viscous liquid with no colour or smell. Old samples can become yellowish, when decomposed in nitrogen oxide and water.

Nowadays, industrial production of Nitric Acid is made using the Ostwald Process, a process that was actually invented by the French chemist Kuhlmann, in which Ammonia was oxidised in the presence of a catalyst. In this process, anhydrous ammonia is oxidized to nitric oxide, in the presence of platinum or rhodium gauge catalyst at high temperature of about K and a pressure of 9 bar. Nitric acid is used in the production of ammonium nitrate for fertilizers, making plastics, and in the manufacture of dyes.

It is also used for making explosives such as nitroglycerin and TNT. When it is combined with hydrochloric acid, an element called aqua regia is formed. This is a reagent that is capable of dissolving gold and platinum.

Additionally, it is used in a colorimetric test to distinguish heroin and morphine. Nitric acid is commonly used in science laboratories at schools for experimenting when specifically testing for chloride.

This is accomplished by adding a sample with silver nitrate solution and nitric acid to test if a white precipitate, silver chloride is present. In the field of medicine, nitric acid is used in its pure state as a caustic to remove chancres and warts. Diluted solutions are used in the treatment of dyspepsia. Nitric acid has been used in various forms as the oxidizer in liquid—fueled rockets. These forms include red fuming nitric acid, white fuming nitric acid, mixtures with sulfuric acid, and forms with HF inhibitor.

In organic synthesis, nitric acid may be used to introduce the nitro group. When used with sulfuric acid, it generates the nitronium ion, which electrophilically reacts with aromatic compounds such as benzene.



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