Wilson J. A comparison of carbenoxolone sodium and deglycyrrhizinated liquorice in the treatment of gastric ulcer in the ambulant patient. Br J Clin Pract. Van Marle J. Deglycyrrhizinised liquorice DGL and the renewal of rat stomach epithelium. Eur J Pharmacol. Goso Y. Effects of traditional herbal medicine on gastric mucin against ethanol-induced gastric injury in rats.
Hajiaghamohammadi A. To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori. Braz J Infect Dis. Epub Sep 8. Morgan A. Maintenance therapy. A two year comparison between Caved-S and cimetidine treatment in the prevention of symptomatic gastric ulcer. Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy.
Turpie A. Clinical trial of deglycyrrhizinised liquorice in gastric ulcer. Rees W. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroent. Kassir Z. Endoscopic controlled trial of four drug regimens in the treatment of chronic duodenal ulceration. Ir Med J. Tewari S. Deglycyrrhizinated liquorice in duodenal ulcer. Das S. Deglycyrrhizinated liquorice in aphthous ulcers.
J Assoc Physicians India. Tanaka Y. Antibacterial compounds of licorice against upper airway respiratory tract pathogens. J Nutr Sci Vitaminol Tokyo ; 47 — Tanaka T.
Novel anti-dysmenorrhea therapy with cyclic administration of two Japanese herbal medicines. Clin Exp Obstet Gynecol. Ofir R. Inhibition of serotonin re-uptake by licorice constituents. J Mol Neurosci. Ikegami N. Prophylactic effect of long-term oral administration of glycyrrhizin on AIDS development of asymptomatic patients. Abstract W. P; Mori K. The present status in prophylaxis and treatment of HIV infected patients with hemophilia in Japan. Rinsho Byhori. Hattori T.
Eisenburg J. Treatment of chronic hepatitis B. Part 2. Effect of glycyrrhizinic acid on the course of illness. Fortschr Med. Acharya S. A preliminary open trial on interferon stimulator SNMC derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure.
Indian J Med Res. Kumada H. Long-term treatment of chronic hepatitis C with glycyrrhizin [stronger neo-minophagen C SNMC ] for preventing liver cirrhosis and hepatocellular carcinoma. Anderson K. Studies in porphyria VII. Relationship of the 5 alpha-reductive metabolism of steroid hormones to clinical expression of the genetic defect in acute intermittent porphyria. Am J Med. Tomita T. Effects of lead and arsenic on the formation of 5 beta-H steroids.
Toxicol Lett. Effect of licorice on the reduction of body fat mass in healthy subjects. J Endocrinol Invest. Kuroda M. Phenolics with PPAR-gamma ligand-binding activity obtained from licorice Glycyrrhiza uralensis roots and ameliorative effects of glycyrin on genetically diabetic KK-A y mice. Bioorg Med Chem Lett.
Mae T. A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats.
J Nutr. History of the endocrine effects of licorice. Exp Clin Endocrinol Diabetes. Fuhrman B. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure.
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Chen M. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Agarwal A. An evaluation of the efficacy of licorice gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study. Anesth Analg. Huang Q. Honda K. The molecular mechanism underlying the reduction in abdominal fat accumulation by licorice flavonoid oil in high fat diet-induced obese rats. Anim Sci J. Kamisoyama H. Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats.
Biosci Biotechnol Biochem. Aoki F. Tominaga Y. Licorice flavonoid oil reduces total body fat and visceral fat in overweight subjects: a randomized, double-blind, placebo-controlled study. Obes Res Clin Prac. Kinoshita T. The effects of licorice flavonoid oil with respect to increasing muscle mass: a randomized, double-blind, placebo-controlled trial. J Sci Food Agric. Epub Nov Clinical safety of licorice flavonoid oil LFO and pharmacokinetics of glabridin in healthy humans.
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Evans F. The rational use of glycyrrhetinic acid in dermatology. Partridge M. Topical carbenoxolone sodium in the management of herpes simplex infection. Br J Oral Maxillofac Surg. Csonka G. Treatment of herpes genitalis with carbenoxolone and cicloxolone creams. A double blind placebo controlled trial.
Br J Vener Dis. Nerya O. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem. Bardhan K. Multicentre Trial Treatment of duodenal ulcers with glycyrrhinizin acid-reduced liquorice. Feldman H. A trial of deglycyrrhizinated liquorice in the treatment of duodenal ulcer. Nazari S. Toxicological effects of Glycyrrhiza glabra licorice : a review. Phytother Res. Epub Aug Belhadj-Tahar H. Acute pseudo-aldosteronism syndrome induced by liquorice.
Al-Qarawi A. Liquorice Glycyrrhiza glabra and the adrenal-kidney-pituitary axis in rats. Tanahashi T. Glycyrrhizic acid suppresses type 2 11 beta-hydroxysteroid dehydrogenase expression in vivo. Sigurjonsdottir H. Liquorice-induced rise in blood pressure: a linear dose-response relationship. J Hum Hypertens. Ploeger B. The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling.
Drug Metab Rev. Van Gelderen C. Glycyrrhizic acid: the assessment of a no effect level. Hum Exp Toxicol. Metabolic studies, aldosterone secretion rate, and plasma renin after carbenoxolone sodium as biogastrone. Licorice consumption and serum testosterone in healthy man. Josephs R. Liquorice consumption and salivary testosterone concentrations. Strandberg T.
Birth outcome in relation to licorice consumption during pregnancy. Am J Epidemiol. Originally from central Europe, licorice now grows all across Europe and Asia. The root is used medicinally. Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings.
We hope this provides you with a helpful resource to make informed decisions towards your health and well-being. For a supplement, little scientific support. Licorice root has a long history of use for soothing inflamed and injured mucous membranes in the digestive tract. Licorice may protect the stomach and duodenum by increasing production of mucin, a substance that protects the lining of these organs against stomach acid and other harmful substances.
According to laboratory research, flavonoids in licorice may also inhibit growth of H. Chamomile has a soothing effect on inflamed and irritated mucous membranes. It is also high in the flavonoid apigenin—another flavonoid that has inhibited growth of H. Many doctors recommend drinking two to three cups of strong chamomile tea each day. The tea can be made by combining 3 to 5 ml of chamomile tincture with hot water or by steeping 2 to 3 tsp of chamomile flowers in the water, covered, for 10 to 15 minutes.
Chamomile is also available in capsules; two may be taken three times per day. Licorice that has had the glycyrrhizic acid removed is called deglycyrrhizinated licorice DGL. Glycyrrhizic acid is the portion of licorice root that can increase blood pressure and cause water retention in some people. The wound-healing and soothing components of the root remain in DGL. A mixture of DGL and warm water applied to the inside of the mouth may shorten the healing time for canker sores, according to a double-blind trial.
It can then be swished in the mouth for two to three minutes, then spit out. This procedure may be repeated each morning and evening for one week. Chewable DGL tablets may be an acceptable substitute. Carminatives are a class of herbs commonly used for infants with colic. These herbs tend to relax intestinal spasms. Chamomile is a carminative with long history of use as a calming herb and may be used to ease intestinal cramping in colicky infants.
A soothing tea made from chamomile, vervain , licorice , fennel , and lemon balm has been shown to relieve colic more effectively than placebo. In a double-blind study, a proprietary product containing marshmallow root , licorice root , and elm bark Throat Coat was effective in providing rapid, temporary relief of sore throat pain in people with acute pharyngitis. Throat Coat was taken as a tea in the amount of 5 to 8 ounces, 4 to 6 times per day, for two to seven days.
The Chinese herb bupleurum is included in two similar Chinese herbal formulae known as sho-saiko-to and saiko-keishi-to; these combinations contain the same herbs but in different proportions. The other ingredients are peony root, pinellia root, cassia bark, ginger root, jujube fruit, Asian ginseng root, Asian scullcap root, and licorice root.
Both formulas have been shown in preliminary trials to be helpful for people with epilepsy. No negative interactions with a variety of anticonvulsant drugs were noted in these trials.
The usual amount taken of these formulas is 2. People with epilepsy should not use either formula without first consulting with a healthcare professional. Licorice , particularly as chewable deglycyrrhizinated licorice DGL , has been shown to be an effective treatment for the healing of stomach and duodenal ulcers ; in an uncontrolled trial, licorice was effective as a treatment for aphthous ulcers canker sores.
A synthetic drug similar to an ingredient of licorice has been used as part of an effective therapy for GERD in both uncontrolled and double-blind trials. In a comparison trial, this combination proved to be as effective as cimetidine Tagamet , a common drug used to treat GERD. However, licorice itself remains unexamined as a treatment for GERD. One of the active constituents in licorice , glycyrrhizin, is sometimes used in Japan as an injected therapy for hepatitis B and C.
Glycyrrhizin also blocks hepatitis A virus from replicating in test tubes. One preliminary trial found that use of 2.
Because glycyrrhizin can cause high blood pressure and other problems, it should only be taken on the advice of a healthcare practitioner. Preliminary trials have shown that the bupleurum -containing formula sho-saiko-to can help reduce symptoms and blood liver enzyme levels in children and adults with chronic active viral hepatitis.
Most of theses trials were in people with hepatitis B infection, though one preliminary trial has also shown a benefit in people with hepatitis C.
Sho-saiko-to was also found, in a large preliminary trial to decrease the risk of people with chronic viral hepatitis developing liver cancer. However, people who had a sign of recent hepatitis B infection were not as strongly protected in this trial. The usual amount of sho-saiko-to used is 2. Sho-saiko-to should not be used together with interferon drug therapy as it may increase risk of pneumonitis - a potentially dangerous inflammation in the lungs.
Licorice has shown the ability to inhibit reproduction of HIV in test tubes. Clinical trials have shown that injections of glycyrrhizin isolated from licorice may have a beneficial effect on AIDS. There is preliminary evidence that orally administered licorice also may be safe and effective for long-term treatment of HIV infection. Amounts of licorice or glycyrrhizin used for treating HIV-positive people warrant monitoring by a physician, because long-term use of these substances can cause high blood pressure , potassium depletion, or other problems.
Approximately 2 grams of licorice root should be taken per day in capsules or as tea. The Chinese herb bupleurum is an important component of the formula known as sho-saiko-to. Sho-saiko-to was shown in one preliminary trial to reduce the risk of liver cancer in people with liver cirrhosis.
The amount of this formula used was 2. Traditionally, herbs that have a soothing action on bronchioles are also used for asthma. These include marshmallow , mullein , hyssop , and licorice. Elecampane has been used traditionally to treat coughs associated with asthma. One case report described a man with CFS whose symptoms improved after taking 2. While there have been no controlled trials to test licorice in patients with CFS, it may be worth a trial of six to eight weeks using 2 to 3 grams of licorice root daily.
Licorice in the form of a cream or gel may be applied directly to herpes sores three to four times per day. Licorice extracts containing glycyrrhizin or glycyrrhetinic acid should be used, as these are the constituents in licorice most likely to provide activity against the herpes simplex virus. There are no controlled trials demonstrating the effectiveness of this treatment, but a cream containing a synthetic version of glycyrrhetinic acid carbenoxolone was reported to speed healing time and reduce pain in people with herpes simplex.
The mucilage of slippery elm gives it a soothing effect for coughs. Usnea also contains mucilage, which may be helpful in easing irritating coughs. There is a long tradition of using wild cherry syrups to treat coughs. Other traditional remedies to relieve coughs include bloodroot , catnip , comfrey the above-ground parts, not the root , horehound , elecampane , mullein , lobelia , hyssop , licorice , mallow , Malvia sylvestris , red clover , ivy leaf , pennyroyal Hedeoma pulegioides, Mentha pulegium , onion , Allium cepa , and plantain Plantago lanceolata, P.
None of these has been investigated in human trials, so their true efficacy for relieving coughs is unknown. A variety of anti-inflammatory herbs historically have been recommended by doctors for people with Crohn's disease. These include yarrow , chamomile , licorice , and aloe juice. Cathartic preparations of aloe should be avoided. No research has been conducted to validate the use of these herbs for Crohn's disease.
Zemaphyte, a traditional Chinese herbal preparation that includes licorice as well as nine other herbs, has been successful in treating childhood and adult eczema in double-blind trials. One or two packets of the combination is mixed in hot water and taken once per day. Because one study included the same amount of licorice in both the placebo and the active medicine, it is unlikely that licorice is the main active component of Zemaphyte.
Several Chinese herbal creams for eczema have been found to be adulterated with steroids. The authors of one study found that 8 of 11 Chinese herbal creams purchased without prescription in England contained a powerful steroid drug used to treat inflammatory skin conditions. Many of the same herbs that are helpful for peptic ulcers may also aid people with gastritis. Licorice root, for example, has been traditionally used to soothe inflammation and injury in the stomach.
Its flavonoid constituents have been found to stall the growth of H. However, there have been no clinical trials using licorice to treat gastritis. To avoid potential side effects, such as increasing blood pressure and water weight gain, many physicians recommend deglycyrrhizinated licorice DGL. This form of licorice retains its healing qualities by removing the glycyrrhizin that causes problems in some people. Licorice root Glycyrrhiza glabra contains antiviral substances and ointments containing related substances are effective in treating herpes infections.
While the use of topical licorice preparations to prevent or treat genital herpes has not been studied, some alternative healthcare practitioners recommend applying creams or gels containing licorice three to four times a day. The Japanese herbal formula known as sho-seiryu-to has been shown to reduce symptom, such as sneezing, for people with hay fever. Sho-seiryu-to contains licorice , cassia bark, schisandra , ma huang, ginger , peony root , pinellia, and asiasarum root.
The Chinese herb bupleurum , as part of the herbal formula sho-saiko-to, has been shown to have beneficial immune effects on white blood cells taken from people infected with HIV. Sho-saiko-to has also been shown to improve the efficacy of the anti-HIV drug lamivudine in the test tube. One preliminary study found that 7 of 13 people with HIV given sho-saiko-to had improvements in immune function.
Other herbs in sho-saiko-to have also been shown to have anti-HIV activity in the test tube, most notably Asian scullcap. This includes famotidine Pepcid and omeprazole Prilosec. Your doctor can also prescribe stronger versions of these medications if necessary. Each form of medication has associated side effects. Antacids can cause diarrhea and constipation. H2 blockers and PPIs can increase your risk for bone fracture or a B12 deficiency. You should work with your doctor to determine the best treatment plan for you.
If you decide to try an alternative therapy, such as DGL, let your doctor know. Learn about other alternative treatments for acid reflux. You can help normalize your overactive bladder naturally by avoiding artificial sweeteners, caffeine, and alcohol, losing weight, and performing…. Learn how wedge pillows can help relieve the symptoms associated with acid reflux and GERD. Learn about acid reflux and when you should see a doctor about acid reflux symptoms. GERD symptoms, such as coughing, nausea, and hoarseness, are affected by what you eat.
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