Who is tong li

Li also is partnering with colleagues to create tau and TDP transgenic mice. The goal is to better understand the genetic susceptibility to TBI, particularly chronic traumatic encephalopathy CTE. Li earned his B. He creates and characterizes transgenic and knockout mouse models to research disease mechanisms and test therapeutic strategies for human diseases. Because abnormal protein aggregation is a common pathologically feature of neurodegenerative disease, Dr.

NFTs consist of hyperphosphorylated tau protein, which is observed in neurodegenerative diseases such as AD, TBI-related dementia, and frontotemporal dementia. A major limitation in the AD field is the lack of a rodent model that faithfully reproduce the tau pathology seen in humans with AD. To address this critical unmet need, Dr. They show that the neuritic plaque is required but not sufficient for the pathological conversion of wild-type tau.

Expression of a human tau repeat domain in mice is also insufficient to drive the pathological conversion of tau. They show that this tau fragment seeds the neuritic plaque-dependent pathological conversion of wild-type tau that spread from the cortex and hippocampus to the brain stem. Chen Lian Xing. Main Role. Gao Da Xia Main Role. Qin Zi Jin Support Role. He Da Ye Main Role. He Da Ye. Guan Yu Qing Main Role.

Jiang Da Lin Main Role. Jiang Da Lin. Wei Xiao [Adult] Guest Role. Shu Jie Main Role. Shu Jie. Lin Yi Yi Main Role. Lin Yi Yi. Meng Qian Xue Main Role. Meng Qian Xue. Tian Run Ye Support Role. Huang Xiao Ying Main Role. Su Jin Main Role. Support Role. He Jing Main Role. He Jing. Wu Tong Main Role. Ge Da Ni Main Role. Ge Da Ni. Yu Hu Xin Main Role. Yu Hu Xin. Miss Chen Ep. An Qi Main Role. Wu Mei Ren Guest Role. Qing Cheng Guest Role. He Xiao Jun Main Role.

He Xiao Jun. Tong Su Yan Main Role. Tong Su Yan. Jing Ru Yi Support Role. Shu Hua Support Role. Xi Lan Support Role. Sun Ya Ting Support Role. Yue Xiao Mei Support Role. Empress Xiao Cheng Support Role. Qi Qiao Main Role. Xu Min Main Role. Song Ai Ling Guest Role. Zhao Ren Lan Main Role.